Grape Seed

Used for its phytonutrient power throughout Europe for hundreds of years.

Grape Seed

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The Science of Grape Seed

Pomoxi’s Grape Seed extract contains Procyanidin B2-3,3″-di-O-gallate (B2G2), a major component of grape seed extract that inhibits key growth factors in cells that drives the overgrowth of cells. Vascular endothelial growth factor (VEGF) is considered the most important growth factor responsible for cell overgrowth, which in scientific terms is called angiogenesis. (1)

Grape Seed extract is more potent antioxidant than pine bark extract and is one the most potent antioxidants known, 20 to 50 times more powerful than Vitamin C or Vitamin E.

Grape Seed extract lowers growth factors at a 10 times lower dose than Vitamin C in human vascular (artery) cells, a growth factor also found in prostate cells. (2)

Grape Seed extract also protects prostate cells against damage from hydrogen peroxide, the most abundant reactive oxygen species found inside human cells. (3)

This botanical extract, ever-growing in popularity for its health benefits, is easily a great choice for a prostate-supporting supplement – mostly because of its potent antioxidant qualities.

In addition to these, grape seed extract also supports your immune system.

What is Grape Seed?

Grape leaves, seeds, fruits, and even the sap have been used successfully as medicine throughout Europe for hundreds of years.

Recently, grape seed extract has become an eminent natural remedy, growing in use and popularity in the Western world and alternative medicine. This extract is a very sustainable supplement because it is derived from the seeds and grape by-products.

The extract is touted for many health benefits such as immune support, heart health, and maintaining healthy blood pressure. However, research around its potential to support prostate health is quite intriguing, and drawing much attention.

Grape seed extract contains unique phytochemicals exhibiting many positive properties, some of which have great implications for prostate health. With the amount of research out there on grape seed extract, this botanical ingredient has shown a lot of promise for helping provide an all-natural, side-effect free prostate support.

Grape Seed’s Therapeutic Compounds

The extract from grape seed in supplement form contains many powerful compounds and phytonutrients.

Among these are: 

  • Bioflavonoids (flavones)
  • Phenols (phenolic acids)

Both of these classes of compounds are highly antioxidant in action, and responsible for grape seed’s noticeable health effects.

One of the most targeted of all these compounds for research is procyanidin, a strong bioflavonoid found in the extract.

Food versus Supplement

Bioflavonoids and phenols can be found within the seed of the grape when eaten. These antioxidants have been detected within red wine making the alcoholic beverage a potential supplement source.

Does this make red wine or even grapes potential candidates as prostate-supporting supplements? Unfortunately, current research indicates otherwise.

Studies on red wine consumption demonstrate little to no correlated effects with prostate health. Additionally, studies on consumption of grape seed alone (as it would be consumed from whole grapes) have shown no valuable correlations, either.

The marked benefits on prostate health in studies have been observed exclusively with grape seed extract, which appears to have higher concentrations of phenols and bioflavonoids than most food sources.

For this reason, someone considering grape seed as a prostate maintenance therapy should choose a concentrated extract or supplement as the best way to have any impact on their prostate health.

Using Grape Seed

There have been ample studies on grape seed extract supplements, many of which advocate for its addition to one’s natural prostate health arsenal. Even doses up to 600 mg (the highest recommended dose for benefit) have shown no alarming or toxic side effects.

This extract has a higher likelihood for prostate support than eating grapes alone, and the science is too substantial to pass up.

Talk to your doctor about taking Pomoxi, a prostate-supporting supplement that can be a great addition to your current regimen. Pomoxi contains grape seed extract, along with many other natural ingredients thoroughly researched for prostate health: such as beta-sitosterols, apigenins, ginger extracts, and more.


1. Kumar R, Deep G, Wempe MF, Agarwal R, Agarwal C. Procyanidin B2 3,3″-di-O-gallate inhibits endothelial cells growth and motility by targeting VEGFR2 and integrin signaling pathways. Curr Cancer Drug Targets. 2015;15(1):14-26.
2. Chao CL, Chang NC, Weng CS, Lee KR, Kao ST, Hsu JC, Ho, FM. Grape seed extract ameliorates tumor necrosis factor-α-induced inflammatory status of human umbilical vein endothelial cells. Eur J Nutr. 2011 Sep;50(6):401-9.
3. Ignea C, Dorobanţu CM, Mintoff CP, Branza-Nichita N, Ladomery MR, Kefalas P, Chedea VS. Modulation of the antioxidant/pro-oxidant balance, cytotoxicity, and antiviral actions of grapeseed extracts. Food Chem. 2013 Dec 15;141(4):3967-76.

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