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Turmeric is a plant that grows in tropical South Asia. Curcumin, Tumeric's active ingredient, is a mixture of curcuminoids produced by the rhizome, or the above-ground root of Curcuma longa. Marco Polo described turmeric in his journals when traveling to India in 1280 and introduced it to the Europeans on his return.

Curcumin is an extract from Turmeric root containing Curcumin C3 Complex®, a blend of naturally-occurring curcuminoids responsible for the health benefits of Turmeric. Curcumin C3 Complex® is the world’s most clinically tested Turmeric extract to provide powerful antioxidant and anti-inflammatory marker-lowering effects. The inflammatory markers that are lowered include the master inflammatory gene NF-kappaB, COX-2, the target of prescription and over-the-counter NSAIDS, and MMPA’s, enzymes that contribute to inflammation in skin, organs, and joints.

Tumor necrosis factor-α (TNF-α) is a key inflammatory compound and its reduction is a therapeutic target. A meta-analysis of clinical trials using Curcumin shows it lowers circulating levels of TNF-α in joint and other inflammatory conditions. TNF-a increases joint synovial fluid inflammation and contributes to cartilage loss, bone erosion and blocks joint repair by preventing new bone cell formation.

Curcumin C3 Complex® also lowers COX-2, the target of over-the counter drugs like aspirin, ibuprofen, and Naproxen without the stomach-irritating and ulcerative side effects of these drugs.

The ORAC (Oxygen Radical Absorbance Capacity) of Curcumin was tested at Brunswick Laboratory against several major free radicals found in the human body: Singlet oxygen, Superoxide radicals, Peroxyl radicals, Hydroxyl radicals, and Peroxynitrite radicals, Curcumin has exhibited high anti-oxidant activity with a total ORAC value, over 150,000 μmole TE/g.

Curcumin and its major metabolite, Tetrahydrocurcumin (THC), increase the lifespan of at least three model organisms: roundworms, fruit flies, and mice.

Some of the research institutions that have conducted clinical trials using Curcumin C3 Complex® are listed here:

• UCLA School of Medicine
• University Hospitals of Cleveland
• MD Anderson Cancer Center
• Rutgers University
• Tufts University School of Medicine
• Massachusetts General Hospital
• Brown University
• Penn State University

The Turmeric extract – Curcumin C3 Complex® – supports prostate health by lowering PSA (Prostate-Specific Antigen) by directly lowering the key inflammatory markers COX-2, NFkB and TNF-a.

Curcumin also lowers growth factors in prostate tissue, lowers testosterone levels and inhibits stem cells.